Determinan Faktor Terjadinya Multidrug Resistant pada Pengobatan TB Paru (MDR-TB) di Rumah Sakit Umum Daerah dr. Zainoel Abidin
DOI:
https://doi.org/10.54259/sehatrakyat.v2i1.1245Keywords:
MDR, Tuberculosis, Demographic Side, Behavior, Side EffectsAbstract
Cases of multidrug resistant tuberculosis (MDR-TB) continue to increase. MDR-TB is the biggest problem in the prevention and eradication of TB, this is thought to have something to do with characteristics, environment, behavior and other disease factors. This study will examine the determinants of MDR-TB in RSUDZA Banda Aceh because it is a referral hospital for MDR-TB examination and treatment in Aceh Province. This type of research is analytic observational with case control design. The population is MDR-TB patients who seek treatment at RSUZA in 2018 as many as 37 people. By using a ratio of 1:1, the number of samples is 74 people consisting of 37 cases and 37 people as controls. Data collection was carried out from 20 to 30 August 2019 using questionnaires and observations. Data analysis used logistic regression test using the Stata program. The results showed that the variables that had significant values were as follows: occupation with the occurrence of MDR-TB (P value = 0.036; OR = 5.6 95%CI: 1.12-28.1), smoking with the occurrence of MDR-TB (P value = 0.034; OR = 2.8, 95% CI: 95% CI: 1.07-7.52), side effects with the occurrence of MDR-TB (P value = 0.006; OR = 5.6, 95% CI: 1.64-1920) and history of diabetes with the occurrence of MDR-TB (P value = 0.001; OR = 4.9, 95% CI: 1.85-13.42). The results of the multivariate analysis obtained a history of DM (OR = 9; 95% CI: 2.53-37.47), (p = 0.0001) meaning that respondents who had a history of DM tended to be 9 times more at risk for MDR-TB compared to other variables. . The Aceh Health Office needs to improve the discovery of MDR-TB cases by conducting gene-expert examinations on TB patients suspected of having MDR-TB.
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References
Aceh, D. (2018). Profil Kesehatan Aceh.
Azhar, K., & Perwitasari, D. (2014). Kondisi fisik rumah dan perilaku dengan prevalensi TB paru di Propinsi Dki Jakarta, Banten dan Sulawesi Utara. Media Penelitian dan Pengembangan Kesehatan, 23(4), 172-181.
Dhewi, G. I. A., Yunie Supriyono, Mamat. (2012). Hubungan antara pengetahuan, sikap pasien dan dukungan keluarga dengan kepatuhan minum obat pada pasien Tb paru di BKPM Pati. Karya Ilmiah S. 1 Ilmu Keperawatan.
Gomes, M., Correia, A., Mendonça, D., & Duarte, R. (2014). Risk factors for drug-resistant tuberculosis. Journal of Tuberculosis Research, 2(03), 111.
Holtz, T. H., Lancaster, J., Laserson, K., Wells, C., Thorpe, L., & Weyer, K. (2006). Risk factors associated with default from multidrug-resistant tuberculosis treatment, South Africa, 1999–2001. The International Journal of Tuberculosis and Lung Disease, 10(6), 649-655.
Katiandagho, D., Fione, V. R., & Sambuaga, J. (2018). Hubungan Merokok Dengan Kejadian TB Paru Di Wilayah Kerja Puskesmas Tatelu Kecamatan Dimembe. Paper presented at the PROSIDING Seminar Nasional Tahun 2018 ISBN: 2549-0931.
Kemenkes, R. (2015). Tuberkulosis ” Temukan, Obati Sampai Sembuh”. Jakarta: Ditjen P2PL.
Kemenkes, R. (2017). Infodatin Tuberkulosis. Jakarta: Pusdatin Kemenkes RI.
Kemenkes, R. (2018). Riset Kesehatan Dasar (RISKESDAS) tahun 2017. Jakarta: Kemenkes RI.
Kizito, K. W., Dunkley, S., Kingori, M., & Reid, T. (2011). Lost to follow up from tuberculosis treatment in an urban informal settlement (Kibera), Nairobi, Kenya: what are the rates and determinants? Transactions of the Royal Society of Tropical Medicine and Hygiene, 105(1), 52-57.
Kusnanto, P., Eko, V., Pakiding, H., & Nurwidiasih, D. (2014). Multidrug resistant tuberculosis (MDR-TB): tinjauan epidemiologi dan faktor risiko efek samping obat anti tuberkulosis. Majalah Kedokteran Bandung, 46(4), 189-196.
Magee, M. J., Kempker, R. R., Kipiani, M., Tukvadze, N., Howards, P. P., Narayan, K. V., & Blumberg, H. M. (2014). Diabetes mellitus, smoking status, and rate of sputum culture conversion in patients with multidrug-resistant tuberculosis: a cohort study from the country of Georgia. PLoS One, 9(4), e94890.
Massi, M. N., Wahyuni, S., Halik, H., Yusuf, I., Leong, F., Dick, T., & Phyu, S. (2011). Drug resistance among tuberculosis patients attending diagnostic and treatment centres in Makassar, Indonesia. The International Journal of Tuberculosis and Lung Disease, 15(4), 489-495.
Mulu, W., Mekkonnen, D., Yimer, M., Admassu, A., & Abera, B. (2015). Risk factors for multidrug resistant tuberculosis patients in Amhara National Regional State. African health sciences, 15(2), 368-377.
Nugrahaeni, D. K. (2015). Analisis penyebab resistensi obat anti tuberkulosis. KEMAS: Jurnal Kesehatan Masyarakat, 11(1), 8-15.
Nurhayati, J. (2014). Hubungan Kinerja Pengawas Menelan Obat terhadap Keberhasilan Pengobatan TB Paru dengan DOTS di RSUP Dr. Kariadi Semarang. Medica Hospitalia-Journal Of Clinical Medicine, 2(1).
Perdana, A. A., & Putra, Y. S. (2018). Hubungan Faktor Lingkungan Fisik Rumah terhadap Kejadian TB Paru di Wilayah Kerja Puskesmas Panjang, Lampung. Jurnal Kesehatan, 9(1), 46-50.
Rifat, M., Milton, A. H., Hall, J., Oldmeadow, C., Islam, M. A., Husain, A., . . . Siddiquea, B. N. (2014). Development of multidrug resistant tuberculosis in Bangladesh: a case-control study on risk factors. PloS one, 9(8), e105214.
Sagwa, E., Mantel-Teeuwisse, A. K., Ruswa, N., Musasa, J. P., Pal, S., Dhliwayo, P., & van Wyk, B. (2012). The burden of adverse events during treatment of drug-resistant tuberculosis in Namibia. Southern med review, 5(1), 6.
Saktiawati, A. M. I., & Subronto, Y. W. (2018). Influence of diabetes mellitus on the development of multi-drug resistant-tuberculosis in Yogyakarta. Indones J Intern Med, 50(1), 7.
Sarwani SR, D., & Nurlaela, S. (2012). Faktor risiko multidrug resistant tuberculosis (MDR-TB). KEMAS: Jurnal Kesehatan Masyarakat, 8(1), 60-66.
Shin, S., Pasechnikov, A., Gelmanova, I., Peremitin, G., Strelis, A., Mishustin, S., . . . Golubchikova, V. (2007). Adverse reactions among patients being treated for MDR-TB in Tomsk, Russia. The International Journal of Tuberculosis and Lung Disease, 11(12), 1314-1320.
Siahaan, A. G., Polii, E. B., & Ongkowijaya, J. (2016). Profil pasien tuberkulosis dengan multi drug resistance (MDR) di RSUP Prof. Dr. RD Kandou periode Agustus 2015-Agustus 2016. e-CliniC, 4(2).
Tachfouti, N., Nejjari, C., Benjelloun, M., Berraho, M., Elfakir, S., El Rhazi, K., & Slama, K. (2011). Association between smoking status, other factors and tuberculosis treatment failure in Morocco. The International Journal of Tuberculosis and Lung Disease, 15(6), 838-843.
WHO, W. H. O. (2017). Global tuberculosis report 2017.
Workicho, A., Kassahun, W., & Alemseged, F. (2017). Risk factors for multidrug-resistant tuberculosis among tuberculosis patients: a case-control study. Infection and drug resistance, 10, 91.
Yoga, A. T. (2013). Tuberkulosis. Jakarta: Perhimpunan Dokter Paru Indonesia.
Shafaati M, Zandi M. (2022). Monkeypox virus neurological manifestations in comparison to other orthopoxviruses. Travel Med Infect Dis. 2022 Aug 2;49:102414. doi: 10.1016/j.tmaid.2022.102414. Epub ahead of print. PMID: 35926767.
Kristi L. Koenig, Christian K. Beÿ, and Aileen M. Marty. (2022). "Monkeypox 2022 Identify-Isolate-Inform: A 3I Tool for frontline clinicians for a zoonosis with escalating human community transmission" One health. doi: 10.1016/j.onehlt.2022.100410
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