Impact of Pre-pregnancy Body Mass Index and The Incidence of Preeclampsia: Systematic Literature Review
DOI:
https://doi.org/10.54259/sehatrakyat.v5i2.7450Keywords:
Preeclampsia, Body Mass Index, Overweight, ObesityAbstract
The incidence of preeclampsia is a leading cause of maternal morbidity and mortality worldwide, where the pre-pregnancy body mass index (BMI) is suspected to be one of the significant risk factors but requires a comprehensive synthesis of evidence. This study aims to analyze and synthesize scientific evidence regarding the influence of pre-pregnancy BMI on the incidence of preeclampsia. The method used is a systematic literature review with article searches in the Google Scholar, PubMed, Proquest, and ScienceDirect databases published in the last 5 years. The review results show that out of the 11 analyzed articles, all studies reported a significant relationship between increased pre-pregnancy BMI and the incident risk of preeclampsia. Woman who are underweight before pregnancy have a lower risk of preeclampsia, while those who are overweight or obese have higher incidence of preeclampsia. Regardless of adjustments for confounding factors, this study present that a high pre-pregnancy BMI is an risk factor for the occurrence of preeclampsia, making weight management before pregnancy very important as an effective primary prevention strategy.
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Abdi, F., Alizadeh, S., Roozbeh, N., Montazeri, F., Banaei, M., Mehrnoush, V., & Darsareh, F. (2025). Prepregnancy overweight and obesity and the risk of adverse pregnancy outcomes. Scientific Reports, 15(1), 1–10. https://doi.org/10.1038/s41598-025-02113-9
ABIM. (2024). Pre-eclampsia & Eclampsia. https://ditki.com/course/usmle-comlex-step-1/glossary/pathophysiologic-disorder/pre-eclampsia-eclampsia-for-usmle-step-1
Abramova, M., Churnosova, M., Efremova, O., Aristova, I., Reshetnikov, E., Polonikov, A., Churnosov, M., & Ponomarenko, I. (2022). Effects of Pre-Pregnancy Overweight/Obesity on the Pattern of Association of Hypertension Susceptibility Genes with Preeclampsia. Life, 12(12). https://doi.org/10.3390/life12122018
Antwi, E., Amoakoh-Coleman, M., Vieira, D. L., Madhavaram, S., Koram, K. A., Grobbee, D. E., Agyepong, I. A., & Klipstein-Grobusch, K. (2020). Systematic review of prediction models for gestational hypertension and preeclampsia. PLoS ONE, 15(4), 1–24. https://doi.org/10.1371/journal.pone.0230955
Çakina, S., Postacı, E. S., & Beyazıt, F. (2025). Oxidative stress in preeclampsia: A comparative biomarker analysis across body mass index categories. Revista Romana de Medicina de Laborator, 33(4), 227–232. https://doi.org/10.2478/rrlm-2025-0024
Cunningham, F.G., Kenneth, J.L., Steven, L.B., John, C.H., Dwight, J.R., Catherine, Y.S., et al. (2022). William Obstetric (26th ed.). McGraw Hill LLC.
Dulay, A. T. (2024). Preeclampsia and Eclampsia. MSD Manual. https://www.msdmanuals.com/professional/gynecology-and-obstetrics/antenatal-complications/preeclampsia-and-eclampsia
Frank, I. O., Michael, J. M., Jenny, R., & Joseph, O. (2020). Prevalence and risk factors for pre-eclampsia/eclampsia in Northern Tanzania. Journal of Public Health and Epidemiology, 12(2), 78–85. https://doi.org/10.5897/jphe2019.1143
Gladstone, R. A., Snelgrove, J. W., McLaughlin, K., Hobson, S. R., Windrim, R. C., Melamed, N., Hladunewich, M., Drewlo, S., & Kingdom, J. C. (2025). Placental growth factor (PlGF) and soluble fms-like tyrosine kinase-1 (sFlt1): powerful new tools to guide obstetric and medical care in pregnancy. Obstetric Medicine, 18(3), 143–149. https://doi.org/10.1177/1753495X251327462
Gong, X., Li, J., Jiang, Y., Yuan, P., Chen, L., Yang, Y., Li, Y., Sun, M., Zhao, Y., Shi, H., & Wei, Y. (2022). Risk of preeclampsia by gestational weight gain in women with varied prepregnancy BMI: A retrospective cohort study. Frontiers in Endocrinology, 13(October), 1–9. https://doi.org/10.3389/fendo.2022.967102
Guo, Y., Lu, J., Bahani, M., Ding, G., Wang, L., Zhang, Y., Zhang, H., Liu, C., Zhou, L., Liu, X., Li, F., Wang, X., & Ding, H. (2024). Triglyceride-glucose index in early pregnancy predicts the risk of gestational diabetes: a prospective cohort study. Lipids in Health and Disease, 23(1), 1–13. https://doi.org/10.1186/s12944-024-02076-2
Huang, S., Mo, Y., Wang, N., Peng, H., Ge, L., Ouyang, W., & Liang, L. (2025). Association between triglyceride glucose-body mass index and preeclampsia risk in advanced maternal age pregnant women-a retrospective cohort study. Scientific Reports, 15(1), 1–11. https://doi.org/10.1038/s41598-025-26463-6
Jancsura, M. K., Schmella, M. J., Helsabeck, N., Gillespie, S. L., Roberts, J. M., Conley, Y. P., & Hubel, C. A. (2023). Inflammatory markers are elevated in early pregnancy, but not late pregnancy, in women with overweight and obesity that later develop preeclampsia. American Journal of Reproductive Immunology, 90(3), 1–8. https://doi.org/10.1111/aji.13763
Kemenkes. (2021). Profil Kesehatan Indonesia.
Kementrian Kesehatan RI. (2020). ANC Terpadu (ketiga). Kementerian Kesehatan RI.
MacKeen, A. D., Boyd, V. E., Schuster, M., Young, A. J., Gray, C., & Angras, K. (2024). The impact of prepregnancy body mass index on pregnancy and neonatal outcomes. Journal of Osteopathic Medicine, 124(10), 447–453. https://doi.org/10.1515/jom-2024-0025
Mao, J., Sun, H., Shen, Q., Zou, C., Yang, Y., & Du, Q. (2025). Impact of pre-pregnancy body mass index on preeclampsia. Frontiers in Medicine, 12(February), 1–8. https://doi.org/10.3389/fmed.2025.1529966
Meilinda, N. (2024). Hubungan IMT dengan kejadian preeklmapsia pada ibu hamil di RSUD Abdul Moeloek. Poltekes Tanjung Karang.
Nakimuli, A., Jasper, B. A., Nakubulwa, S., Adroma, M., Akello, J., Namagembe, I., Sekikubo, M., Nakabembe, E., Moffett, A., & Aiken, C. E. (2025). Risk factors associated with progression from pre-eclampsia to eclampsia: A prospective cohort study and population-wide data analysis. Acta Obstetricia et Gynecologica Scandinavica, 104(8), 1487–1495. https://doi.org/10.1111/aogs.15154
Norris, J. M., Ball, B. R., Freemanc, A., Kirkhamd, A., Parrye, M. A., Moorea, C. M., Whitakera, H. C., & Emberton, M. (2021). A Modified Newcastle-Ottawa Scale for the Assessment of Study Quality in Genetic Urological Research Joseph M. Norris. A Modified NOS for Assessment of Study Quality in Genetic Urological Research, 1–5.
Page, M. J., McKenzie, J. E., Bossuyt, P. M., Boutron, I., Hoffmann, T. C., Mulrow, C. D., Shamseer, L., Tetzlaff, J. M., Akl, E. A., Brennan, S. E., Chou, R., Glanville, J., Grimshaw, J. M., Hróbjartsson, A., Lalu, M. M., Li, T., Loder, E. W., Mayo-Wilson, E., McDonald, S., Moher, D. (2021). The PRISMA 2020 statement: An updated guideline for reporting systematic reviews. Bmj, 372. https://doi.org/10.1136/bmj.n71
Pankiewicz, K., Szczerba, E., Fijałkowska, A., Sierdziński, J., Issat, T., & Maciejewski, T. M. (2022). The Impact of Coexisting Gestational Diabetes Mellitus on the Course of Preeclampsia. Journal of Clinical Medicine, 11(21), 6390. https://doi.org/10.3390/jcm11216390
Sun, M., Luo, M., Wang, T., Wei, J., Zhang, S., Shu, J., Zhong, T., Liu, Y., Chen, Q., Zhu, P., & Qin, J. (2023). Effect of the interaction between advanced maternal age and pre-pregnancy BMI on pre-eclampsia and GDM in Central China. BMJ Open Diabetes Research and Care, 11(2). https://doi.org/10.1136/bmjdrc-2023-003324
van Hoorn, F., de Wit, L., van Rossem, L., Jambroes, M., Groenendaal, F., Kwee, A., de Ruiter, M. L., Franx, A., van Rijn, B. B., Koster, M. P. H., & Bekker, M. N. (2021). A prospective population-based multicentre study on the impact of maternal body mass index on adverse pregnancy outcomes: Focus on normal weight. PLoS ONE, 16(9 September), 1–17. https://doi.org/10.1371/journal.pone.0257722
Veiga, E. C. de A., Korkes, H. A., Salomão, K. B., & Cavalli, R. C. (2022). Association of LEPTIN and other inflammatory markers with preeclampsia: A systematic review. Frontiers in Pharmacology, 13(August), 1–10. https://doi.org/10.3389/fphar.2022.966400
WHO. (2017). ANC Guidline. https://platform.who.int/docs/default-source/mca-documents/policy-documents/guideline/brb-mn-21-01-guideline-2017-eng-guidelines-for-antenatal-care-in-barbados-revised-feb-2017.pdf
World Health Organization (WHO). (2025). Pregnancy Book (1st ed.). Health and Social Care.
Xue, Y., Juan, J., Shu, X., He, Y., Cao, K., Kang, X., Huang, H., & Yang, H. (2025). Associations between maternal glycemic level and lipid profile and adverse pregnancy outcomes in women with type 2 diabetes mellitus: a retrospective study from China. PeerJ, 13, 1–18. https://doi.org/10.7717/peerj.19502
Zahid, S., Tanveer ud Din, M., Minhas, A. S., Rai, D., Kaur, G., Carfagnini, C., Khan, M. Z., Ullah, W., Van Spall, H. G. C., Hays, A. G., & Michos, E. D. (2022). Racial and Socioeconomic Disparities in Cardiovascular Outcomes of Preeclampsia Hospitalizations in the United States 2004-2019. JACC: Advances, 1(3), 100062. https://doi.org/10.1016/j.jacadv.2022.100062
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