Pure Decompression versus Decompression with Fusion in Degenerative Lumbar Spondylolisthesis: A Meta-Analysis of Long-Term Outcomes

Penulis

  • Andika Prasetyo Arifin QADR Hospital
  • M. Yogi Alamsyah Dr. Esnawan Antariksa Air Force Hospital
  • Arimurti Pratianto Permata Bekasi Hospital
  • Rheza Fabianto Sebastian QADR Hospital

DOI:

https://doi.org/10.54259/sehatrakyat.v5i3.7406

Kata Kunci:

Decompression, Degenerative Lumbar Spondylolisthesis, Oswestry Disability Index, Instrumented Fusion, Spinal Fusion

Abstrak

Degenerative lumbar spondylolisthesis is a common spinal problem seen in everyday practice, especially in older adults, and it often presents with ongoing low back pain, neurogenic claudication, and radicular symptoms. Although decompression surgery is generally considered effective for relieving neural compression, whether fusion should be added at the same time is still controversial, particularly when long-term results and resource use are taken into account. This meta-analysis followed PRISMA guidelines. We systematically searched PubMed, the Cochrane Library, and Google Scholar for randomized controlled trials involving adults with degenerative lumbar spondylolisthesis. The main outcomes were functional disability measured by the Oswestry Disability Index (ODI), along with separate assessments of low back pain and leg pain. Data were pooled in Review Manager 5.4 using fixed- or random-effects models as appropriate, and results were reported with 95% confidence intervals. Across the three included trials, the two surgical strategies performed similarly overall. There were no meaningful differences in ODI scores or in reported back and leg pain. Decompression alone was linked to a slightly higher reoperation rate, but the difference was not statistically significant. In contrast, adding fusion led to longer operative times and longer hospital stays, without providing a clear clinical benefit. Taken together, these findings suggest that decompression without fusion may be a simpler, more resource-efficient choice for carefully selected patients with degenerative lumbar spondylolisthesis who do not have instability or major deformity. That said, the evidence is still limited by the small number of trials and relatively short follow-up. Larger, well-designed studies with longer observation are needed to better determine how durable the outcomes are and what the true reoperation risk is.

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Referensi

Austevoll, I. M., Hermansen, E., Fagerland, M. W., Storheim, K., Brox, J. I., Solberg, T., Rekeland, F., Franssen, E., Weber, C., Brisby, H., Grundnes, O., Algaard, K. R. H., Boker, T., Banitalebi, H., Indrekvam, K., & Hellum, C. (2021). Decompression with or without Fusion in Degenerative Lumbar Spondylolisthesis. New England Journal of Medicine, 385(6), 526–538. https://doi.org/10.1056/NEJMoa2100990

Arimbawa, I. B. G., et al. (2022). Comparison between decompression alone and with additional fusion for degenerative lumbar spondylolisthesis: A systematic review and meta-analysis. Spine Surgery and Related Research, 7(1), 42–51. https://doi.org/10.22603/ssrr.2022-0011

Chen, Z., Zhao, J., & Xu, H. (2021). Decompression alone versus decompression with fusion for lumbar degenerative spondylolisthesis: a meta-analysis of randomized controlled trials. World Neurosurgery, 146, e1020–e1030. https://doi.org/10.1016/j.wneu.2020.11.154

Dea, N., Fisher, C. G., & Batke, J. (2020). Current treatment strategies for degenerative lumbar spondylolisthesis: a systematic review. Global Spine Journal, 10(2 Suppl), 190S-199S. https://doi.org/10.1177/2192568219889089

Forsth, P., Olafsson, G., Carlsson, T., Frost, A., Borgstrom, F., Fritzell, P., & Ohagen, P. (2016). A Randomized, Controlled Trial of Fusion Surgery for Lumbar Spinal Stenosis. New England Journal of Medicine, 374(15), 1413–1423. https://doi.org/10.1056/NEJMoa1513721

Gadjradj, P. S., Harhangi, B. S., & Amelink, J. (2022). Decompression alone versus decompression with fusion in patients with degenerative lumbar spondylolisthesis: a systematic review and meta-analysis. European Spine Journal, 31(4), 765–777. https://doi.org/10.1007/s00586-021-07062-0

Ghogawala, Z., Dziura, J., Butler, W. E., Dai, F., Terrin, N., Magge, S. N., Coumans, J.-V., Harrington, J. F., Amin-Hanjani, S., Schwartz, J. S., Sonntag, V. K. H., Barker, F. G., & Benzel, E. C. (2016). Laminectomy plus Fusion versus Laminectomy Alone for Lumbar Spondylolisthesis. New England Journal of Medicine, 374(15), 1424–1434. https://doi.org/10.1056/NEJMoa1508788

Guo, J., Fan, Y., Diao, H., Fan, J., Zhang, J., Li, J., Xiao, D., Su, R., Zhang, Y., & Sun, T. (2025). Evaluation of the therapeutic effect of decompression with or without fusion on lumbar spinal stenosis caused by degenerative lumbar spondylolisthesis: A systematic review and meta-analysis. World Neurosurgery, 194, Article 123512. https://doi.org/10.1016/j.wneu.2024.123512

Inose, H., Kato, T., Yuasa, M., Yamada, T., Maehara, H., Hirai, T., Yoshii, T., Kawabata, S., & Okawa, A. (2018). Comparison of Decompression, Decompression Plus Fusion, and Decompression Plus Stabilization for Degenerative Spondylolisthesis: A Prospective, Randomized Study. Clinical Spine Surgery, 31(7), 302–308.

Kaiser, R., et al. (2023). Decompression alone versus decompression with instrumented fusion in the treatment of lumbar degenerative spondylolisthesis: A systematic review and meta-analysis of randomised trials. Journal of Neurology, Neurosurgery & Psychiatry.

Karlsson, T., Försth, P., Öhagen, P., Michaëlsson, K., & Sandén, B. (2024). Decompression alone or decompression with fusion for lumbar spinal stenosis: Five-year clinical results from a randomized clinical trial. The Bone & Joint Journal, 106-B(7), 705–712. https://doi.org/10.1302/0301-620X.106B7.BJJ-2023-1160.R2

Martin, B. I., Mirza, S. K., Karamian, B. A., Schoenfeld, A. J., Ko, H., Suri, P., & Brodke, D. S. (2026). Cost and utilization trends of lumbar fusion. JAMA Network Open, 9(3), Article e260452. https://doi.org/10.1001/jamanetworkopen.2026.0452

Mazurek, M., et al. (2023). Factors predisposing to the formation of degenerative spondylolisthesis A narrative review. Medicina, 59(8), Article 1430. https://doi.org/10.3390/medicina59081430

Karlsson, T., Forsth, P., Ohagen, P., Michaelsson, K., & Sanden, B. (2024). Decompression alone or decompression with fusion for lumbar spinal stenosis: five-year clinical results from a randomized clinical trial. Bone & Joint Journal, 106-B(7), 705–712.

Kgomotso, E. L., Hellum, C., Fagerland, M. W., Solberg, T., Brox, J. I., Storheim, K., Hermansen, E., Franssen, E., Weber, C., Brisby, H., & Austevoll, I. M. (2024). Decompression alone or with fusion for degenerative lumbar spondylolisthesis (Nordsten-DS): five year follow-up of a randomised, multicentre, non-inferiority trial. BMJ, 386, e079771. https://doi.org/10.1136/bmj-2024-079771

Pranata, R., et al. (2022). Decompression alone compared to decompression with fusion for lumbar degenerative spondylolisthesis: A systematic review and meta-analysis.

Wei, F. L., Zhou, C. P., & Liu, R. (2020). Decompression alone versus fusion for lumbar spinal stenosis: a meta-analysis. Journal of Orthopaedic Surgery and Research, 15, 56. https://doi.org/10.1186/s13018-020-01656-1

Diterbitkan

2026-08-07

Cara Mengutip

Andika Prasetyo Arifin, M. Yogi Alamsyah, Arimurti Pratianto, & Rheza Fabianto Sebastian. (2026). Pure Decompression versus Decompression with Fusion in Degenerative Lumbar Spondylolisthesis: A Meta-Analysis of Long-Term Outcomes. Sehat Rakyat: Jurnal Kesehatan Masyarakat, 5(3), 1212–1225. https://doi.org/10.54259/sehatrakyat.v5i3.7406

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