Systematic Journal Review: Recent Developments in The Diagnosis and Therapeutic Management of Sinonasal Carcinoma
DOI:
https://doi.org/10.54259/sehatrakyat.v5i1.6203Keywords:
Biomarker, Diagnosis, Human Papillomavirus (HPV), Radiotherapy, Sinonasal CarcinomaAbstract
Sinonasal carcinoma is a rare aggressive malignancy often detected at an advanced stage due to non-specific initial symptoms. This systematic review aims to summarize recent advances in diagnosis, including imaging technology and biomarkers, and to analyze current therapy management modalities to provide evidence-based recommendations. This study used a Systematic Journal Review (SLR) design following PRISMA guidelines to ensure transparency and accuracy, with a comprehensive literature search from databases such as PubMed and Scopus. Analyzed articles were limited to the last five years (2020-2025) and were narratively synthesized with data extraction covering diagnostic modalities, therapeutic strategies, and clinical outcomes. Trend and density visualization maps revealed a divided research focus: the clinical management cluster (sinonasal cancer, radiotherapy) as the foundation, and the diagnostic cluster (differential diagnosis, SMARCA4-deficient sinonasal ca) as the cutting-edge innovation. Analyzed studies confirmed the importance of genetic biomarkers such as SMARCA4 and HPV status for prognosis and therapy personalization. Overall, the current literature highlights a shift towards multimodal approaches and precision oncology that integrates molecular diagnosis to improve patient outcomes. This review confirms the integration of molecular diagnosis and personalized therapy management as the latest trend in sinonasal carcinoma treatment.
Downloads
References
Agaimy, A., Jain, D., Uddin, N., Rooper, L. M., & Bishop, J. A. (2020). SMARCA4-deficient sinonasal carcinoma: a series of 10 cases expanding the genetic spectrum of SWI/SNF-driven sinonasal malignancies. The American Journal of Surgical Pathology, 44(5), 703–710. https://doi.org/10.1097/PAS.0000000000001428
Awais, M., Ali, A., Khattak, M. S., Arfeen, M. I., Chaudhary, M. A. I., & Syed, A. (2023). Strategic Flexibility and Organizational Performance: Mediating Role of Innovation. SAGE Open, 13(2). https://doi.org/10.1177/21582440231181432
Bhai, P., Turowec, J., Santos, S., Kerkhof, J., Pickard, L., Foroutan, A., Breadner, D., Cecchini, M., Levy, M. A., Stuart, A., Welch, S., Howlett, C., Lin, H., & Sadikovic, B. (2023). Molecular profiling of solid tumors by next-generation sequencing: an experience from a clinical laboratory. Frontiers in Oncology, 13, 1208244. https://doi.org/10.3389/fonc.2023.1208244
Binazzi, A., di Marzio, D., Mensi, C., Consonni, D., Miligi, L., Piro, S., Zajacovà, J., Sorasio, D., Galli, P., Camagni, A., Calisti, R., Massacesi, S., Cozzi, I., Balestri, A., Murano, S., Fedeli, U., Comiati, V., Eccher, S., Lattanzio, S., & Marinaccio, A. (2024). Gender differences in sinonasal cancer incidence: Data from the Italian registry. Cancers, 16(11), 2053. https://doi.org/10.3390/cancers16112053
Bracigliano, A., Tatangelo, F., Perri, F., Di Lorenzo, G., Tafuto, R., Ottaiano, A., Clemente, O., Barretta, M. L., Losito, N. S., Santorsola, M., & Tafuto, S. (2021). Malignant sinonasal tumors: Update on histological and clinical management. Current Oncology, 28(4), 2420–2438. https://doi.org/10.3390/curroncol28040222
Chmielewski, P. P. (2024). Clinical anatomy of the paranasal sinuses and its terminology. Anatomical Science International, 99, 454–460. https://doi.org/10.1007/s12565-023-00745-3
Consonni, D., Stella, S., Denaro, N., Binazzi, A., Dallari, B., Rugarli, S., Borello, F., Coviello, E., & Mensi, C. (2024). Survival of patients with sinonasal cancers in a population-based registry, Lombardy, Italy, 2008–2023. Cancers, 16(5), 896. https://doi.org/10.3390/cancers16050896
El-Adem, D., Yang, N., & Gudis, D. A. (2023). The role of positron emission tomography for the management of sinonasal malignancies: A systematic review. American Journal of Rhinology & Allergy, 37(5), 593–610. https://doi.org/10.1177/19458924231177854
Elgart, K., & Faden, D. L. (2020). Sinonasal squamous cell carcinoma: etiology, pathogenesis, and the role of human papilloma virus. Current Otorhinolaryngology Reports, 8(2), 111–119. https://doi.org/10.1007/s40136-020-00279-6
Ferrari, M., Taboni, S., Carobbio, A. L. C., Emanuelli, E., Maroldi, R., Bossi, P., & Nicolai, P. (2021). Sinonasal squamous cell carcinoma, a narrative reappraisal of the current evidence. Cancers, 13(11), 2835. https://doi.org/10.3390/cancers13112835
Indrasari, S. R., Herdini, C., Yudistira, D., & Mary, C. (2023). Prevalence of sinonasal cancer in Dr. Sardjito General Hospital Yogyakarta in the period between January 2017 and December 2022. Indonesian Journal of Cancer.
Lumbanraja, P. C., Lumbanraja, L., Koperasi, D., Perindustrian, D., Asahan, K., Pt, ), Perkebunan, R., & Bogor, N. (2023). Cendekia Niaga Journal of Trade Development and Studies Analisis Variabel Ekonomi Hijau (Green Economy Variable) Terhadap Pendapatan Indonesia (Tahun 2011-2020) dengan Metode SEM-PLS.
Mauthe, T., Holzmann, D., Soyka, M. B., Mueller, S. A., Balermpass, P., Held, U., Freiberger, S. N., Rupp, N. J., & Meerwein, C. M. (2023). Overall and disease-specific survival of sinonasal adenoid cystic carcinoma: a systematic review and meta-analysis. Rhinology, 61(6), 508–518. https://doi.org/10.4193/Rhin23.204
Millen, R., De Kort, W. W. B., Koomen, M., van Son, G. J. F., Gobits, R., Penning de Vries, B., Begthel, H., Zandvliet, M., Doornaert, P., Raaijmakers, C. P. J., Geurts, M. H., Elias, S. G., van Es, R. J. J., de Bree, R., Devriese, L. A., Willems, S. M., Kranenburg, O., & Clevers, H. (2023). Patient-derived head and neck cancer organoids allow treatment stratification and serve as a tool for biomarker validation and identification. Med, 4(5), 290-310.e12. https://doi.org/10.1016/j.medj.2023.04.003
Page, M. J., McKenzie, J. E., Bossuyt, P. M., Boutron, I., Hoffmann, T. C., Mulrow, C. D., Shamseer, L., Tetzlaff, J. M., Akl, E. A., Brennan, S. E., Chou, R., Glanville, J., Grimshaw, J. M., Hróbjartsson, A., Lalu, M. M., Li, T., Loder, E. W., Mayo-Wilson, E., McDonald, S., & Moher, D. (2021). The PRISMA 2020 statement: An updated guideline for reporting systematic reviews. BMJ, 372, n71. https://doi.org/10.1136/bmj.n71
Papadopoulou, A.-M., Chrysikos, D., Samolis, A., Tsakotos, G., & Troupis, T. (2021). Anatomical variations of the nasal cavities and paranasal sinuses: A systematic review. Cureus, 13(2), e12727. https://doi.org/10.7759/cureus.12727
Paver, E. C., Currie, A. M., Gupta, R., & Dahlstrom, J. E. (2020). Human papilloma virus related squamous cell carcinomas of the head and neck: diagnosis, clinical implications and detection of HPV. Pathology, 52(2), 179–191. https://doi.org/10.1016/j.pathol.2019.10.008
Rooper, L. M., Uddin, N., Gagan, J., Brosens, L. A. A., Magliocca, K. R., Edgar, M. A., Thompson, L. D. R., Agaimy, A., & Bishop, J. A. (2020). Recurrent loss of SMARCA4 in sinonasal teratocarcinosarcoma. The American Journal of Surgical Pathology, 44(10), 1331–1339. https://doi.org/10.1097/PAS.0000000000001508
Taverna, C., Agaimy, A., & Franchi, A. (2022). Towards a molecular classification of sinonasal carcinomas: Clinical implications and opportunities. Cancers, 14(6), 1463. https://doi.org/10.3390/cancers14061463
Thawani, R., Kim, M. S., Arastu, A., Feng, Z., West, M. T., Taflin, N. F., Thein, K. Z., Li, R., Geltzeiler, M., Lee, N., Fuller, C. D., Grandis, J. R., Floudas, C. S., Heinrich, M. C., Hanna, E., & Chandra, R. A. (2023). The contemporary management of cancers of the sinonasal tract in adults. CA: A Cancer Journal for Clinicians, 73(1), 72–112. https://doi.org/10.3322/caac.21752
Thompson, L. D. R., & Bishop, J. A. (2022). Update from the 5th Edition of the World Health Organization classification of head and neck tumors: nasal cavity, paranasal sinuses and skull base. Head and Neck Pathology, 16(1), 1–18. https://doi.org/10.1007/s12105-021-01406-5
Vuong, T. D. N., & Nguyen, L. T. (2022). The Key Strategies for Measuring Employee Performance in Companies: A Systematic Review. Sustainability, 14(21), 14017. https://doi.org/10.3390/su142114017
Williams, J., Kostiuk, M., & Biron, V. L. (2022). Molecular detection methods in HPV-related cancers. Frontiers in Oncology, 12, 864820. https://doi.org/10.3389/fonc.2022.864820
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2026 Tolkha Amaruddin
This work is licensed under a Creative Commons Attribution 4.0 International License.
Hak cipta pada setiap artikel adalah milik penulis.
Penulis mengakui bahwa SEHATRAKYAT (Jurnal Kesehatan Masyarakat) sebagai publisher yang mempublikasikan pertama kali dengan lisensi Creative Commons Attribution 4.0 International License.
Penulis dapat memasukan tulisan secara terpisah, mengatur distribusi non-ekskulif dari naskah yang telah terbit di jurnal ini kedalam versi yang lain, seperti: dikirim ke respository institusi penulis, publikasi kedalam buku, dan lain-lain. Dengan mengakui bahwa naskah telah terbit pertama kali pada SEHATRAKYAT (Jurnal Kesehatan Masyarakat).
